There are four types or combinations of pharmaceutical manufacturers: bulk products, semi-finished products, active ingredients, and FDA-approved pharmaceutical products. Bulk drugs and semi-finished products are usually made by fine chemical companies. Vacuum pump applications: crystallization, distillation, extraction, sublimation, drying, deodorization, degassing, crystallization/vaporization, polymerization, vacuum evaporation, negative pressure filtration, monomer recovery, adsorption/desorption, material transportation, etc.

The following vacuum pump applications can be used to produce the above medical products:

 

Drying (tray, spin, flip, cone and freeze dryer)

Drying is a low cost, relatively low temperature treatment process in which the biological or active ingredients are not damaged/degraded/oxidized by the evaporation of liquid from the solid by reducing the vacuum. Dry medical/biological products, remove solvents, water, etc., with special requirement that the vacuum in the final drying section is less than 1torr. After drying, what is left is a granular preparation that is pressed into tablets. The remaining moisture level is low, which can prolong the storage life of the product.

 

Reproduction/reactor drying

Reactors are used in the fine chemical, medical and aromatic industries. Vacuum devices are used to reduce/control reaction temperatures, remove reactants, reduce costs and control/improve product quality, and grab products.

Many chemical reaction and applied drying pump technologies include medical semi-finished products, neutralization and adsorption chemical reactions, desorption/cracking of hydrocarbons and other chemical products, and synthesis of compounds.

 

Distillation

Distillation is the separation of two or more layers or parts that have different temperatures, pressures, compositions, and phases. As the distillation column becomes more balanced, the parts have different concentrations and can be separated from the mixed species. The distillation column provides air pressure to separate the different components of the liquid by varying the vacuum and temperature.

The vacuum system removes noncoagulants, water, and light hydrocarbons from the system, allowing the feedstock to be treated through the distillation column for separation. Condenses the gas discharged from the top of the distillation column, returns the liquid to the distillation column for partial separation, and is typically used for fatty acids, glycerol hydrochloric acid, vitamins (A, E), oils, fats, paraffins, insecticides and plasticizers.

 

In addition to gas

Degassing is the removal of dissolved/retained gases from a liquid or product. Vacuum devices can remove gases from liquids, improve their physical properties, improve product quality for further treatment, and avoid cross contamination or corrosion.

Here is a simple list of uses:

Degassing oil to improve purity (hydrocarbon oil, insulation oil, turbine oil, brake fluid and hydraulic brake oil, etc.)

Degassing gels, ointments and paints to remove excess gas that may harden or degrade product quality

The polymer is degamed in the extruder to achieve higher product quality or to obtain bubble-free parts

Degassing for medicine, food and water in boilers.

 

Crystallization/vaporization

Crystallization is the evaporation and cooling of an oversaturated liquid to form crystals. These crystals are easy to carry, store and sell. For this application, our vacuum pumps are ideal for controlling evaporation/cooling rates across all pressure ranges and reducing production costs by reducing the boiling point of liquids.

 

These applications include:

Concentration: distillation, discharge, radioactive waste, black liquor, sugar, beet

Recovery of gold-plated materials, photographic solutions

Production of ammonium nitrate and sodium hydroxide

Crystal sugar, salt, tampons, aniline, urea, calcium sulfate, potassium carbonate, amino acids, penicillin and antibiotics

When filling and/or material transfer, milk and paste are injected into the piping, etc., air shall be discharged from the inside. This can be done with a small liquid ring pump or a rotary impeller pump on a refilling machine. A vacuum pump is used to add the liquid into the tank and then expel it through the compressor, thus achieving the transfer of the liquid.